We describe the national health research ethics review system of Uzbekistan and identify policy and program gaps that impede the protection of human research subjects. We find that the National Ethic Committee (NEC), functioning at the national level, is solely responsible for conducting research ethics review. There is little evidence that regional ethics committees work as intended, and there is no research ethics review at medical institutes and research centers even though they conduct CDTs (clinical drug trials). There is no (...) national policy for the ethical review of non-clinical trials. We recommend the establishment of institutional review boards (IRBs) at medical institutes and research centers while at the same time building capacity at the national level to oversee and support the research ethics review system of the entire country. (shrink)

The purpose of the study is to reveal the genesis of the concept of digital reality and its connection with the millennial Pyphagorean tradition in European philosophy and culture, based on the logic and dialectic of the number as a metaphysical entity. The article implements an attempt to historically and philosophically consider the phenomenon of digital reality: the conclusions of modern researchers are confirmed about the key importance of this philosophical tradition as a special system of thought, which defined modern (...) ideological and scientific paradigms and contributed to the formation of the social model of post-industrial, information-digital society. Scientific novelty is to reveal a modern scientific understanding of the notion that numbers can materialize the world by reflecting reality and returning it to man through knowledge derived through the programming or construction of digital reality on the basis of symbolic-applied logic. As a result of the analysis of philosophical sources, it has been proved that information in our world can be considered as another kind of movement of matter, and the Internet is not only an "information technology" but a "social form", a "universal social space" that appeared not overnight – with the invention of "breakthrough" technology, but formed by centuries of cultivated scientific knowledge. (shrink)